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Genentech
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Stephen Lillington’s indexed work centers on the metabolic capabilities and enzymatic machinery of anaerobic fungi, particularly their role in degrading complex plant matter. His primary research, as seen in his highly cited overview of anaerobic microbial communities driving crude biomass deconstruction, explores how these organisms function as specialized recyclers in natural environments. Further investigations led by Lillington have utilized advanced imaging to demonstrate that cellulosome localization patterns vary across different life stages of these fungi, suggesting a sophisticated spatial regulation of their digestive enzymes. His more recent first-author contributions have focused on the molecular level, specifically the expression and characterization of spore coat CotH kinases found within fungal cellulosomes. Beyond his lead-author studies, Lillington has contributed to high-impact collaborative research, including a study with over 100 citations regarding lignin deconstruction by anaerobic fungi. He has also been involved in efforts toward designing chimeric enzymes inspired by fungal cellulosomes to improve synthetic biotechnological processes. His recent activity indicates a shift toward computational biology and protein engineering, evidenced by his work on CDR conformation-aware antibody sequence design using the ConformAb framework. Collectively, these outputs reflect a research arc that moves from characterizing natural biomass-degrading systems toward the engineering of complex proteins and therapeutic sequences.
Thomas S Lankiewicz, Hemant Choudhary, Yu Gao, Bashar Amer, Stephen P Lillington, Patrick A Leggieri, Jennifer L Brown, Candice L Swift, Anna Lipzen, Hyunsoo Na, Mojgan Amirebrahimi, Michael K Theodorou, Edward E K Baidoo, Kerrie Barry, Igor V Grigoriev, Vitaliy I Timokhin, John Gladden, Seema Singh, Jenny C Mortimer, John Ralph, Blake A Simmons, Steven W Singer, Michelle A O'Malley
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Stephen P Lillington, Patrick A Leggieri, Kellie A Heom, Michelle A O'Malley
Sean P Gilmore, Stephen P Lillington, Charles H Haitjema, Randall de Groot, Michelle A O'Malley
Stephen P Lillington, William Chrisler, Charles H Haitjema, Sean P Gilmore, Chuck R Smallwood, Vaithiyalingam Shutthanandan, James E Evans, Michelle A O'Malley
Thomas S Lankiewicz, Stephen P Lillington, Michelle A O'Malley