The Role: 

Generate Biomedicines is seeking a Research Associate II/Senior Research Associate to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting-edge structural biology, contributing to our mission of accelerating drug discovery through advanced imaging technologies.

Here's how you will contribute:

• Perform protein purification, complexation, vitrification, and clipping, ensuring high-quality sample preparation for CryoEM.
• Load and operate CryoEM microscopes, executing data collection with automated workflows.
• Collaborate with multidisciplinary teams to support high-throughput protein structure determination.
• Follow standard operating procedures (SOPs) and contribute to process optimization.
• Document experimental data and report findings in internal databases.
• Interpret and troubleshoot experimental data, contributing to planning and prioritization of concurrent CryoEM experiments.
• Apply and refine data analysis methods; determine reliability of results and communicate findings in presentations or team meetings.
• Contribute to process optimization and implementation of new protocols.

The Ideal Candidate will have:

• MSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field and 0-2+ years of experience, or a BSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field with 2-4+ years of related experience.
• Hands-on experience in basic wet lab techniques, including pipetting, buffer preparation, and protein purification.
• Strong understanding of protein chemistry concepts, such as molarity, protein concentration, and buffer formulation.
• Ability to work in a fast-paced, collaborative research environment.
• Strong attention to detail and ability to troubleshoot technical issues.

Preferred Additional Skills

• Familiarity with structural biology techniques and CryoEM sample preparation.
• Prior exposure to CryoEM workflows or microscope operation with SerialEM.

Who Will Love This Job:

• You’re excited to learn fast and build deep expertise in CryoEM and structural biology—this role offers hands-on training with advanced instrumentation, real ownership of experiments, and the chance to grow your technical skillset alongside experienced scientists.

Additional Information
On-site position at our Andover, MA CryoEM lab
Location: Andover, MA (On-site, 5 days/week)

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About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.