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Shimon Sakaguchi’s indexed work centers on the biology of regulatory T cells (Tregs) and their role in immune tolerance. His most-cited contributions include the identification of Foxp3 as the master transcription factor controlling Treg development, a finding established in his 2003 senior-author paper, and the delineation of CTLA-4 as a key effector molecule in Foxp3+ Treg function, reported in his 2008 Science paper. His first-author reviews, including those in Cell and Annual Review of Immunology, have systematically framed the field’s understanding of naturally arising CD4+ Tregs in self-tolerance and immune regulation. Later work extends this framework to translational settings, with his 2016 review addressing the role of Tregs in cancer immunotherapy. Beyond his lead-author publications, Sakaguchi contributed as a co-author to a 2013 Nature study demonstrating that a rationally selected mixture of Clostridia strains from the human microbiota induces Tregs, a key early collaboration linking commensal bacteria to immune regulation. His broader portfolio also includes a 2009 Immunity paper on the functional delineation of human CD4+ T cells expressing Foxp3, and a 2000 Journal of Experimental Medicine study establishing the constitutive expression of CTLA-4 on CD25+CD4+ Tregs. Taken together, his body of work traces a coherent arc from fundamental mechanisms of Treg development and function to their therapeutic implications in autoimmunity and cancer, with no additional software or dataset outputs indexed.
Atsushi Tanaka, Shimon Sakaguchi
Masahiko Akamatsu, Norihisa Mikami, Naganari Ohkura, Ryoji Kawakami, Yohko Kitagawa, Atsushi Sugimoto, Keiji Hirota, Naoto Nakamura, Satoru Ujihara, Toshio Kurosaki, Hisao Hamaguchi, Hironori Harada, Guliang Xia, Yoshiaki Morita,
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Atsushi Tanaka, Hiroyoshi Nishikawa, Shinsuke Noguchi, Daisuke Sugiyama, Hiromasa Morikawa, Yoshiko Takeuchi, Danbee Ha, Naoya Shigeta, Toshio Kitawaki, Yuka Maeda, Takuro Saito, Yoshinori Shinohara, Yoshihiro Kameoka, Keiko Iwaisako, Fumihiko Monma, Kohshi Ohishi, Julia Karbach, Elke Jäger, Kenichi Sawada, Naoyuki Katayama, Naoto Takahashi, Shimon Sakaguchi
Yusuke Takeuchi, Keiji Hirota, Shimon Sakaguchi
Yang Yang, Xiao Li, Zhihai Ma, Chunlin Wang, Qunying Yang, Miranda Byrne-Steele, Rongjian Hong, Qing Min, Gao Zhou, Yong Cheng, Guang Qin, Justin V Youngyunpipatkul, James B Wing, Shimon Sakaguchi, Christian Toonstra, Lai-Xi Wang, Jose G Vilches-Moure, Denong Wang, Michael P Snyder, Ji-Yang Wang, Jian Han, Leonore A Herzenberg