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Franklin W. Stahl’s research centers on the fundamental mechanisms of genetic inheritance and molecular biology. His most influential indexed work includes the 1958 demonstration of semiconservative DNA replication in Escherichia coli, a foundational study cited over 1,200 times that clarified how genetic material duplicates. Publicly indexed outputs suggest a long-term focus on the mechanics of genetic exchange, notably through the development of the double-strand-break repair model for recombination. This 1983 model, which has garnered nearly 2,500 citations, provided a theoretical framework for understanding how DNA breaks are processed to facilitate genetic diversity and genomic integrity across different organisms. Beyond these primary models, Stahl’s portfolio includes significant contributions to the biophysical study of genetic material, such as his early involvement in developing equilibrium sedimentation of macromolecules in density gradients. His later research transitioned into complex eukaryotic systems, evidenced by his work on crossover interference in Arabidopsis, which explores how the positioning of genetic exchanges is regulated during meiosis. The arc of his contribution is defined by a consistent inquiry into how DNA is broken, repaired, and rearranged, moving from the study of bacteriophage "hot spots" to broader applications in yeast and plant genetics. These works collectively establish a rigorous molecular basis for the field of genetic recombination.
J W Szostak, T L Orr-Weaver, R J Rothstein, F W Stahl
D R Leach, F W Stahl
F W Stahl, J M Crasemann, M M Stahl
Franklin W Stahl, Henriette M Foss, Lisa S Young, Rhona H Borts, M F F Abdullah, Gregory P Copenhaver
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