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David Baltimore’s indexed research primarily investigates the molecular mechanisms of gene regulation and viral replication. His foundational work includes the discovery of viral RNA-dependent DNA polymerase in RNA tumor viruses, a finding that fundamentally altered the understanding of genetic information flow. Much of his highly cited output centers on the NF-κB transcription factor family, including research into the induction of microRNA miR-146 as an inhibitor of innate immune signaling and the critical role of NF-κB in preventing TNF-α-induced cell death. These senior-authored contributions, which have collectively earned thousands of citations, clarify how cells respond to external stimuli and maintain survival under stress. The researcher’s broader portfolio extends into the structural biology of DNA binding and the development of molecular tools. He has contributed significantly to identifying the helix-loop-helix dimerization motif in immunoglobulin enhancer and myc proteins, as well as characterizing the specific inhibition of NF-κB by the IκB protein. His work also bridges basic science and clinical relevance, evidenced by the production of high-titer helper-free retroviruses via transient transfection for gene delivery and the modeling of leukemia induction in mice using the bcr/abl gene. Together, these outputs reflect a career-long focus on the regulatory circuits governing immunology, virology, and cancer biology.
Luke Frankiw, David Baltimore, Guideng Li
Susan P Foy, Kyle Jacoby, Daniela A Bota, Theresa Hunter, Zheng Pan, Eric Stawiski, Yan Ma, William Lu, Songming Peng, Clifford L Wang, Benjamin Yuen, Olivier Dalmas, Katharine Heeringa, Barbara Sennino, Andy Conroy, Michael T Bethune, Ines Mende, William White, Monica Kukreja, Swetha Gunturu, Emily Humphrey, Adeel Hussaini, Duo An, Adam J Litterman, Boi Bryant Quach, Alphonsus H C Ng, Yue Lu, Chad Smith, Katie M Campbell, Daniel Anaya, Lindsey Skrdlant, Eva Yi-Hsuan Huang, Ventura Mendoza, Jyoti Mathur, Luke Dengler, Bhamini Purandare, Robert Moot, Michael C Yi, Roel Funke, Alison Sibley, Todd Stallings-Schmitt, David Y Oh, Bartosz Chmielowski, Mehrdad Abedi, Yuan Yuan, Jeffrey A Sosman, Sylvia M Lee, Adam J Schoenfeld, David Baltimore, James R Heath, Alex Franzusoff, Antoni Ribas, Arati V Rao, Stefanie J Mandl
Aude I Segaliny, Guideng Li, Lingshun Kong, Ci Ren, Xiaoming Chen, Jessica K Wang, David Baltimore, Guikai Wu, Weian Zhao
Guideng Li, Michael T Bethune, Stephanie Wong, Alok V Joglekar, Michael T Leonard, Jessica K Wang, Jocelyn T Kim, Donghui Cheng, Songming Peng, Jesse M Zaretsky, Yapeng Su, Yicheng Luo, James R Heath, Antoni Ribas, Owen N Witte, David Baltimore
Alok V Joglekar, Michael T Leonard, John D Jeppson, Margaret Swift, Guideng Li, Stephanie Wong, Songming Peng, Jesse M Zaretsky, James R Heath, Antoni Ribas, Michael T Bethune, David Baltimore
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