Dan H. Barouch

Research Statement

AI generated · 1d ago

Dan H. Barouch's indexed work centers on vaccine and antibody strategies against viral pathogens, developed and tested largely in nonhuman primate models. His most-cited senior-author studies established correlates of protection against SARS-CoV-2 in rhesus macaques and demonstrated DNA vaccine protection against SARS-CoV-2 in the same model, while his earlier first-author work showed that cytokine-augmented DNA vaccination could control viremia and prevent clinical AIDS in rhesus monkeys. Related studies mapped viral escape from cytotoxic T lymphocytes as a route to eventual AIDS vaccine failure and characterized potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected animals. Beyond these, he contributed to an immunogenic personal neoantigen vaccine for patients with melanoma and to trials of the single-dose Ad26.COV2.S Covid-19 vaccine, reflecting middle-author roles in high-impact consortia. No software, datasets, patents, or grants are indexed beyond publications. Collaborators such as Barney S. Graham and Bruce D. Walker appear within this shared vaccine and immunology space. Taken together, the listed works trace a consistent line from early HIV vaccine and reservoir science toward rapid COVID-19 vaccine and antibody development.

Most Cited Works

Correlates of protection against SARS-CoV-2 in rhesus macaques

Katherine McMahan, Jingyou Yu, Noe B Mercado, Carolin Loos, Lisa H Tostanoski, Abishek Chandrashekar, Jinyan Liu, Lauren Peter, Caroline Atyeo, Alex Zhu, Esther A Bondzie, Gabriel Dagotto, Makda S Gebre, Catherine Jacob-Dolan, Zhenfeng Li, Felix Nampanya, Shivani Patel, Laurent Pessaint, Alex Van Ry, Kelvin Blade, Jake Yalley-Ogunro, Mehtap Cabus, Renita Brown, Anthony Cook, Elyse Teow, Hanne Andersen, Mark G Lewis, Douglas A Lauffenburger, Galit Alter, Dan H Barouch

Nature2020

Research Areas

HIV Research and TreatmentSARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune ResponsesVirus-based gene therapy researchvaccines and immunoinformatics approache

Affiliations & Education

Education

Harvard Medical School(US)
M.D. · Medicine
Oxford University(GB)
D.Phil. · Immunology
1998–2026
Harvard University(US)
A.B. · Biochemistry

Employment

1998–2026

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Sources

Research Statement

Most Cited Works

Correlates of protection against SARS-CoV-2 in rhesus macaques

Research Areas

Affiliations & Education

Education

Employment

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

Animal models for COVID-19

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma