Boxuan Simen Zhao

Boxuan Simen Zhao | JRNLClub

Research Statement

AI generated · 2d ago

Boxuan Simen Zhao's indexed research centers on epitranscriptomic regulation by mRNA modifications, particularly how m6A and pseudouridine shape gene expression. His most-cited lead-author review, on post-transcriptional gene regulation by mRNA modifications, has accumulated over 2,400 citations and frames much of this agenda. In zebrafish, he showed that m6A-dependent maternal mRNA clearance drives the maternal-to-zygotic transition. Related first-author work connects RNA methylation to stem cell pluripotency, extending the same mechanistic thread into developmental and fertility contexts. Beyond these lead-author pieces, his overall record includes middle-author contributions to widely cited studies, including work on m6A modulation of mRNA translation efficiency and on IGF2BP recognition of m6A enhancing mRNA stability. More recently, as senior author, he developed Connectome-seq, a high-throughput method for mapping neuronal connectivity at single-synapse resolution via barcode sequencing, signaling a methodological turn toward neural circuit mapping. No software tools, datasets, patents, or grants appear in the indexed data beyond these publications. The arc runs from chemical-probe and RNA-modification biology toward scalable sequencing-based measurement of neural connectivity.

Most Cited Works

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Xiao Wang, Boxuan Simen Zhao, Ian A Roundtree, Zhike Lu, Dali Han, Honghui Ma, Xiaocheng Weng, Kai Chen, Hailing Shi, Chuan He

Cell2015

3,484Citations

Post-transcriptional gene regulation by mRNA modifications

Boxuan Simen Zhao, Ian A Roundtree, Chuan He

Nature Reviews Molecular Cell Biology2016

Research Areas

RNA modifications and cancerRNA regulation and diseaseEpigenetics and DNA MethylationRNA Research and SplicingMetal-Organic Frameworks: Synthesis and

Affiliations & Education

Education

2013–present· now
University of Chicago(US)
Ph.D. · Chemistry Department
2012–2013
University of Chicago(US)
M.S. · Chemistry Department
2008–2012
Peking University(CN)
B.S. · Department of Chemical Biology, College of Chemistry

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Boxuan Simen Zhao

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