Aparna Bhaduri

Research Statement

AI generated · 1d ago

Aparna Bhaduri studies how the developing human cortex builds its diverse cell types, and how those programs go wrong in cancer. Her most-cited lead-author work uses cortical organoids to show that cell stress impairs molecular subtype specification, a caution for disease modeling, while a companion study maps cortical arealization and its dynamic molecular signatures across the developing brain. She has also applied single-cell approaches to glioblastoma, identifying outer radial glia-like cancer stem cells as a source of tumor heterogeneity, work that has drawn over 400 citations. Beyond these, she contributed to consortium-scale efforts, including single-cell genomic identification of cell type-specific molecular changes in autism and spatiotemporal gene expression trajectories of human cortical developmental hierarchies, both with Arnold R. Kriegstein. Her later senior-author work includes an integrated atlas of modules driving developmental cell subtype specification in the human cortex and a human tumor-immune organoid model of glioblastoma. No software, datasets, patents, or grants are indexed beyond her publications. Across these studies, her trajectory runs from computational sequence analysis toward building and interrogating human brain models to explain normal development and its disruption in disease.

Most Cited Works

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

Tomasz J Nowakowski, Aparna Bhaduri, Alex A Pollen, Beatriz Alvarado, Mohammed A Mostajo-Radji, Elizabeth Di Lullo, Maximilian Haeussler, Carmen Sandoval-Espinosa, Siyuan John Liu, Dmitry Velmeshev, Johain Ryad Ounadjela, Joe Shuga, Xiaohui Wang, Daniel A Lim, Jay A West, Anne A Leyrat, W James Kent, Arnold R Kriegstein

Science2017

1,009Citations

Single-cell genomics identifies cell type–specific molecular changes in autism

Research Areas

Glioma Diagnosis and TreatmentNeurogenesis and neuroplasticity mechaniMeningioma and schwannoma managementSingle-cell and spatial transcriptomicsBone Tumor Diagnosis and Treatments

Affiliations & Education

Employment

2021–present· now
University of California, Los Angeles(US)
Assistant Professor · Biological Chemistry

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