Ann Sarah Walker

Research Statement

AI generated · 1d ago

Ann Sarah Walker's indexed work centers on the epidemiology and genomic surveillance of bacterial infections, particularly Clostridium difficile transmission in hospital wards, traced through whole-genome sequencing and extensive epidemiological data. Her senior-authored study identifying diverse sources of C. difficile infection remains her most-cited, while first-author analyses linked bacterial strain type and host biomarkers to mortality in C. difficile infection. A parallel line examines long COVID symptom trajectories after vaccination, alongside earlier HIV research on co-trimoxazole prophylaxis in immunosuppressed adults starting antiretroviral therapy in Africa. Beyond these, she contributed as a middle author to consortium work on the global burden of bacterial antimicrobial resistance, and to trials comparing oral versus intravenous antibiotics for bone and joint infection and tracking antibody status and SARS-CoV-2 incidence in health care workers. Her methodological interests appear in work on how genomic diversity affects bacterial SNP-calling accuracy, and in genomic epidemiology of tuberculosis outbreaks with Daniel J. Wilson. No software, datasets, or patents are indexed beyond her publications. Across these outputs, the through-line is applying sequencing and cohort methods to antibiotic resistance, transmission, and infection outcomes.

Most Cited Works

Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050

GBD 2021 Antimicrobial Resistance Collaborators

The Lancet2024

3,917Citations

Oral versus Intravenous Antibiotics for Bone and Joint Infection

Ho-Kwong Li, Ines Rombach, Rhea Zambellas, A Sarah Walker, Martin A McNally, Bridget L Atkins, Benjamin A Lipsky, Harriet C Hughes, Deepa Bose, Michelle Kümin, Claire Scarborough, Philippa C Matthews, Andrew J Brent, Jose Lomas, Roger Gundle

Research Areas

Antibiotic Use and ResistanceHIV/AIDS Research and InterventionsHIV/AIDS drug development and treatmentAntibiotic Resistance in BacteriaSARS-CoV-2 and COVID-19 Research

Affiliations & Education

Employment

2009–2026
University of Oxford(GB)
NDM Experimental Medicine
2013–2026
University College London(GB)

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Sources