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Alexander F. Schier's research centers on the molecular and genetic mechanisms that drive vertebrate embryogenesis, using the zebrafish as a primary model. His most-cited work established foundational principles in this area, including the discovery that microRNAs regulate brain morphogenesis and clear maternal mRNAs during early development, a finding that reshaped understanding of post-transcriptional control in embryos. His lab also pioneered the use of single-cell reconstruction of developmental trajectories during zebrafish embryogenesis, providing a high-resolution atlas of cell fate decisions. Complementing these biological insights, his group developed efficient Cas9-mediated mutagenesis and single-guide RNA assessment, a widely adopted tool for targeted genome editing, and demonstrated how zebrafish behavioral profiling links drugs to biological targets, opening new avenues for neuroactive compound discovery. Beyond his lead-author contributions, Schier has been a key collaborator on several high-impact projects. He contributed to spatial reconstruction of single-cell gene expression data, a landmark method that maps transcriptomic information back to tissue architecture, and participated in the classic genetic screen for mutations affecting embryogenesis in zebrafish, which laid the groundwork for the field. His broader portfolio also includes whole-organism lineage tracing by combinatorial and cumulative genome editing and brain-wide neuronal dynamics during motor adaptation, reflecting a sustained focus on integrating genetic, imaging, and computational approaches. Together, these works trace a coherent arc from identifying essential developmental signals to building the technological frameworks that enable modern, high-resolution studies of vertebrate biology.
Rahul Satija, Jeffrey A Farrell, David Gennert, Alexander F Schier, Aviv Regev
Antonio J Giraldez, Yuichiro Mishima, Jason Rihel, Russell J Grocock, Stijn Van Dongen, Kunio Inoue, Anton J Enright, Alexander F Schier
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W Driever, L Solnica-Krezel, A F Schier, S C Neuhauss, J Malicki, D L Stemple, D Y Stainier, F Zwartkruis, S Abdelilah, Z Rangini, J Belak, C Boggs
Antonio J Giraldez, Ryan M Cinalli, Margaret E Glasner, Anton J Enright, J Michael Thomson, Scott Baskerville, Scott M Hammond, David P Bartel, Alexander F Schier
James A Gagnon, Eivind Valen, Summer B Thyme, Peng Huang, Laila Akhmetova, Andrea Pauli, Tessa G Montague, Steven Zimmerman, Constance Richter, Alexander F Schier