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Alejandro Chavez’s indexed work centers on CRISPR-based tools for transcriptional programming and genome engineering, anchored by his first-author studies on highly efficient Cas9-mediated activation and cross-species comparisons of Cas9 activators. His more recent senior-authored efforts pivot to coronavirus 3CL protease biology, including functional maps of protease tolerance and immutable sites, as well as cell-based assays for inhibitor identification. Earlier first-author contributions also probe DNA repair mechanisms, specifically the role of the Smc5/6 complex in homologous recombination and senescence, alongside a review of helicase actions at telomeres. Beyond his lead-author portfolio, Chavez contributed as a middle author to several high-impact collaborative works, including the landmark study on age-related clonal hematopoiesis and adverse outcomes, an orthogonal CRISPR interference platform for mycobacteria, and an enhanced CRISPR repressor for mammalian gene regulation. He also participated in work on SARS-CoV-2 resistance to nirmatrelvir and a genome-wide RNAi screen for polyglutamine aggregation regulators. His most recent senior-authored output describes high-throughput tagging of endogenous loci for rapid protein function characterization. Collectively, these works trace a trajectory from foundational CRISPR engineering to viral protease vulnerabilities and genome-scale functional genomics, reflecting a sustained focus on developing and applying genetic tools across biological systems.
Nan Cher Yeo, Alejandro Chavez, Alissa Lance-Byrne, Yingleong Chan, David Menn, Denitsa Milanova, Chih-Chung Kuo, Xiaoge Guo, Sumana Sharma, Angela Tung, Ryan J Cecchi, Marcelle Tuttle, Swechchha Pradhan, Elaine T Lim, Noah Davidsohn, Mo R Ebrahimkhani, James J Collins, Nathan E Lewis, Samira Kiani, George M Church
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Sho Iketani, Hiroshi Mohri, Bruce Culbertson, Seo Jung Hong, Yinkai Duan, Maria I Luck, Medini K Annavajhala, Yicheng Guo, Zizhang Sheng, Anne-Catrin Uhlemann, Stephen P Goff, Yosef Sabo, Haitao Yang, Alejandro Chavez, David D Ho
Yinkai Duan, Hao Zhou, Xiang Liu, Sho Iketani, Mengmeng Lin, Xiaoyu Zhang, Qucheng Bian, Haofeng Wang, Haoran Sun, Seo Jung Hong, Bruce Culbertson, Hiroshi Mohri, Maria I Luck, Yan Zhu, Xiaoce Liu, Yuchi Lu, Xiuna Yang, Kailin Yang, Yosef Sabo, Alejandro Chavez, Stephen P Goff, Zihe Rao, David D Ho, Haitao Yang
Sho Iketani, Farhad Forouhar, Hengrui Liu, Seo Jung Hong, Fang-Yu Lin, Manoj S Nair, Arie Zask, Yaoxing Huang, Li Xing, Brent R Stockwell, Alejandro Chavez, David D Ho
Hengrui Liu, Sho Iketani, Arie Zask, Nisha Khanizeman, Eva Bednarova, Farhad Forouhar, Brandon Fowler, Seo Jung Hong, Hiroshi Mohri, Manoj S Nair, Yaoxing Huang, Nicholas E S Tay, Sumin Lee, Charles Karan, Samuel J Resnick, Colette Quinn, Wenjing Li, Henry Shion, Xin Xia, Jacob D Daniels, Michelle Bartolo-Cruz, Marcelo Farina, Presha Rajbhandari, Christopher Jurtschenko, Matthew A Lauber, Thomas McDonald, Michael E Stokes, Brett L Hurst, Tomislav Rovis, Alejandro Chavez, David D Ho, Brent R Stockwell