Is this you?
Sign in with ORCID to claim this profile — instantly verify it’s yours, curate your publications, and take control of how your work appears here.
Recent publications · auto-generated until this profile is claimed
Alec C. Kimmelman’s indexed work centers on the metabolic and autophagic dependencies that sustain pancreatic cancer. As senior author on several highly cited studies, he identified NCOA4 as the cargo receptor mediating ferritinophagy (2014, 2037 citations) and demonstrated that pancreatic cancers require autophagy for tumor growth (2011, 1479 citations). His research further showed that glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway (2013, 1994 citations) and that autophagy promotes immune evasion by degrading MHC-I (2020, 1246 citations). These contributions collectively establish autophagy as a critical mechanism in pancreatic tumor biology. Kimmelman has also contributed to broader frameworks in the field, including a consensus piece on understanding cancer-associated fibroblasts (2020, Nature Reviews Cancer, 3866 citations) and a study on oncogenic Kras maintaining tumors through anabolic glucose metabolism (2012, Cell, 2068 citations). His work on targeting autophagy in cancer (2019, Cancer Discovery, 959 citations) and a phase II trial of hydroxychloroquine for autophagy inhibition in metastatic pancreatic cancer (2014, The Oncologist, 374 citations) reflect translational efforts alongside mechanistic discovery. Across these studies, Kimmelman’s research has consistently illuminated how metabolic and autophagic pathways sustain pancreatic tumors and may be exploited therapeutically.
Joel Encarnación-Rosado, Albert S W Sohn, Douglas E Biancur, Elaine Y Lin, Victoria Osorio-Vasquez, Tori Rodrick, Diana González-Baerga, Ende Zhao, Yumi Yokoyama, Diane M Simeone, Drew R Jones, Seth J Parker, Robert Wild, Alec C Kimmelman
Subhadip Mukhopadhyay, Joel Encarnación-Rosado
0 publications
0 other materials
No GitHub profile linked
Alpha1 Science activity will appear here once this profile is claimed.
Mohamad Assi, Alec C Kimmelman
Samantha Guinn, Benedict Kinny-Köster, Joseph A Tandurella, Jacob T Mitchell, Dimitrios N Sidiropoulos, Melanie Loth, Melissa R Lyman, Alexandra B Pucsek, Daniel J Zabransky, Jae W Lee, Emma Kartalia, Mili Ramani, Toni T Seppälä, Christopher Cherry, Reecha Suri, Haley Zlomke, Jignasha Patel, Jin He, Christopher L Wolfgang, Jun Yu, Lei Zheng, David P Ryan, David T Ting, Alec Kimmelman, Anuj Gupta, Ludmila Danilova, Jennifer H Elisseeff, Laura D Wood, Genevieve Stein-O'Brien, Luciane T Kagohara, Elizabeth M Jaffee, Richard A Burkhart, Elana J Fertig, Jacquelyn W Zimmerman
Mohamad Assi, Ruohong Wang, Emily A. Kawaler, Albert S.W. Sohn, M. Zahidunnabi Dewan, Despoina Kalfakakou, Joel Encarnacion-Rosado, Kevin S. Kapner, Koelina Ganguly, Joao A. Paulo, Diane M. Simeone, Andrew J. Aguirre, Robert S. Banh, Alec C. Kimmelman