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Aditya Raguram’s indexed work centers on therapeutic in vivo delivery of gene editing agents, particularly through the engineering of virus-like particles (VLPs). His first-author *Cell* paper on this topic, which has garnered over 500 citations, established a framework for packaging and delivering gene-editing payloads in living animals. He subsequently advanced this approach by directed evolution of engineered VLPs with improved production and transduction efficiencies, reported in *Nature Biotechnology*, and has most recently led a genome-wide screening effort, as senior author in *Nature Communications*, to identify producer-cell modifications that further enhance VLP potency. Beyond his lead-author contributions, Raguram has been a key collaborator on foundational genome-editing technologies. He contributed to the development of prime editing and base editing systems, including the landmark *Nature* paper on search-and-replace editing and the *Nature Biotechnology* work on improving cytidine and adenine base editors. These middle-author efforts, alongside work on compact prime editors and twin prime editing, reflect a sustained focus on engineering the molecular tools and delivery vehicles that enable precise genetic modification.
Andrew V Anzalone, Peyton B Randolph, Jessie R Davis, Alexander A Sousa, Luke W Koblan, Jonathan M Levy, Peter J Chen, Christopher Wilson, Gregory A Newby, Aditya Raguram, David R Liu
Luke W Koblan, Jordan L Doman, Christopher Wilson, Jonathan M Levy, Tristan Tay, Gregory A Newby, Juan Pablo Maianti, Aditya Raguram, David R Liu
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Qiupeng Lin, Yuan Zong, Chenxiao Xue, Shengxing Wang, Shuai Jin, Zixu Zhu, Yanpeng Wang, Andrew V Anzalone, Aditya Raguram, Jordan L Doman, David R Liu, Caixia Gao
Beverly Y Mok, Marcos H de Moraes, Jun Zeng, Dustin E Bosch, Anna V Kotrys, Aditya Raguram, FoSheng Hsu, Matthew C Radey, S Brook Peterson, Vamsi K Mootha, Joseph D Mougous, David R Liu
Samagya Banskota, Aditya Raguram, Susie Suh, Samuel W Du, Jessie R Davis, Elliot H Choi, Xiao Wang, Sarah C Nielsen, Gregory A Newby, Peyton B Randolph, Mark J Osborn, Kiran Musunuru, Krzysztof Palczewski, David R Liu